저자들은 상복부 불편감과 소화불량을 있는 환자에서 췌장 미부에 선암종을 동반한 파골세포양 거대세포 미분화 암종을 진단하였고, 수술적 절제 후 방사선 치료와 항암화학요법을 시행한 예를 경험하였기에 문헌고찰과 함께 보고한다.

Undifferentiated carcinomas with osteoclast-like giant cells are rare pancreatic and periampullary neoplasms that mimic giant cell tumors of bone morphologically. Recently, we experienced an osteoclast-like giant cell tumor arising in the tail of the pancreas. A 76-year-old male was admitted with epigastric discomfort and indigestion. Abdominal computed tomography (CT) and abdominal magnetic resonance imaging (MRI) showed a 3×3-cm mass containing necrotic and hemorrhagic areas in the tail of the pancreas. A distal pancreatectomy and splenectomy were performed. Histological examination showed tumor cell components consisting of mononuclear pleomorphic cells admixed with osteoclastic giant cells. The final diagnosis was undifferentiated carcinoma with osteoclast-like giant cells with ductal adenocarcinoma in the pancreas. (Korean J Med 2011;80:82-86)