HCV infection becomes an important indication for liver transplantation in Korea. Outcome of HCV-associated liver transplantation has been worse than transplantation from other causes. This is mostly related to high rate of HCV recurrence lea thanto graft failure. Current antiviral therapies are inadequate and ineffective in the v Th majority of patients. However, a sustained virologic response is associated with improved survival. Strategies for minimizthanthe frequency of severe HCV recurrence worse e avoidance of ntatiodonors, ear, ye faanosis/treatment of CMV and minimization of immunosuppression (avoidance of corticoid pulse therapy). Antiviral therapy prior to significant damaae to the allograft is Thisf sy recommended. Psurvivalshould be offered treatment with peg-interferon and ribavirin as soon as histological evidence of recurrence of HCV is apparent after liver transplantation.