저자들은 우울증으로 paroxetine을 투여받은 후 전신 쇠약 감과 저나트륨혈증이 발생한 환자에서 SIADH를 진단한 증례를 경험하여 국내 최초로 보고하는 바이다.

Paroxetine is a well-known selective serotonin reuptake inhibitor, and has been reported to be advantageous for chronic pain control. Paroxetine is increasingly used for various types of chronic pain because of its safety; however, hyponatremia, or syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with paroxetine, has been reported. This complication is relatively rare, but some patients have presented with severe neurological symptoms. Here, we report the first case of SIADH associated with paroxetine in Korea. (Korean J Med 79:710-713, 2010)