Kaposi`s sarcoma (KS) is a multifocal, systemic tumor of an endothelial cell origin and there are four clinical subtypes. Among these clinical subtypes, KS associated with immunosuppressive therapy mainly develops in organ transplant patients as well as in other patients who are receiving immunosuppressants for other reasons. It can occur from 1 month to more than 10 years after starting the agent and it seems to depend on the dose and type of the drug taken. We report here on a case of diffuse cutaneous iatrogenic Kaposi`s sarcoma that was associated with 2 years of oral corticosteroid therapy. The patient`s disease was present as various forms of cutaneous lesions without any systemic involvement. (Korean J Dermatol 2010;48(10):884~888)