Objective: The purpose of this study is to observe the effects of herbal-acupuncture with Acanthopanacis cortex extract (AC-HA) at KI10 (Eumgok) on osteoporosis in ovariectomized (OVX) ddy mice. Methods: We carried out several experimental items to analyze the changes in body weight, uterine weight, uterus index, tibial Length, the ash bone weight, tibial BMD, serum ALP, serum creatinine, serum osteocalcin, serum Ca, and the Levels of Ca, P, Ca/P ratio in tibia, and we performed histological and histomorphological analysis as well. Results: Tibial BMD was significantly decreased by OVX, while significantly increased by AC-HA at KI10. Serum creatinine Level was significantly increased by OVX, while significantly decreased by AC-HA at KI10. Serum osteocalcin Level was significantly increased by OVX, while significantly decreased by AC-HA at KI10. Tibial TBV(trabecular bone volume) was significantly decreased by OVX, while significantly increased by AC-HA at KI10. AC-HA at KI10 significantly suppressed the OVX-induced increase of GPL(growth plate Length) of tibia in mice. Conclusion : These results suggest that AC-HA at KI10 has a therapeutic effect on osteoporosis in OVX mice.