Objective: This study aimed to evaluate the effects of Plantaginis Semen herbal-acupuncture (PS-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide (LPS) in rat. Methods: The authors performed several experimental items including measurements of urinary volume, WBC in blood, BUN, creatine, TNF-α, CINC-1 in serum, creatinine, total protein in urine, TNF-α, MPO in kidney and histological analysis of renal tissue. Results: PS-HA at KI10 significantly reduced WBC in blood, BUN, TNF-α in serum of LPS-stimulated rats. PS-HA at KI10 significantly increased urinary volume in LPS-stimulated rats. And PS-HA at KI10 significantly reduced MPO in kidney of LPS-stimulated rats. Conclusion: Taken together, PS-HA at KI10 has a therapeutic effect on nephritis in LPS-stimulated rat. Therefore, it is suggested that PS-HA at KI10 may be an useful therapeutics for nephritis in clinical field.