Objective: To make comprehensive feature of previous researches on moxibustion, then build a basis of strategy for development of moxibustion-derived therapeutics. Methods: Surveyed 326 abstraction-containing Literatures from total 467 of moxibustion-related papers in PubMed and 29 papers in Korea. Analysis was performed according to distribution by study subject, number by year, nation, research method, and its efficacy. Results: Moxibustion-related researches have been rapidly increased since 2001. The main contributive country for moxibustion research was China whileas few researches was done by Korea. The main subjects of moxibustion research are associated with immunity, inflammation, neurosystem, and digestive function. The most therapeutic roles of moxibustion were on pain control, modulation of immunity, anti-fatigue and anti-stress. Conclusion: This study will help Korean Oriental medical doctors to systematically review the moxibustion researches, and to develop more competitive therapeutics using moxibustion in global CAM field.