Objectives & Methods: The purpose of this study is to observe the effects of Angelicae Radix Pharmacopuncture(AR-P) at Joksamni(ST36) on collagen Ⅱ induced arthritis in DBA/1J mice. The authors evaluated arthritis index, arthritis incidence and joint edema, and measured body weight, spleen size and stenosis rate, serum cytokine level, serum antibody level, immune cell populations in spleen, lymph node, and knee joint, and performed histological analysis of CIA mouse joint. Results: In the AR-P group, arthritis index, arthritis incidence and joint edema were decreased, and the enlargement, malformation and stenosis of spleen and the malformation of joint appeared milder than the control group. In AR-P group, the levels of IL-1β, IL-6, TNF-α, IFN-γ in serum were significantly decreased. And the level of anti-collagen Ⅱ in serum was maintained lower in AR-P group than in the control group. In AR-P group, the level of IFN-γ and IL-10, and IFN-γ/IL-4 ratio were significantly decreased, and the ratios of CD3e+ cells to CD45+ cells, CD4+ cells to CD8+ cells in spleen were similarly maintained as those of the normal group. In the AR-P group, the populations of CD4+/CD25+ cells in spleen and lymph nodes, CD45R+/CD69+ cells in lymph nodes, CD3+/CD69+ cells and CD11b+/Gr-1+ cells in knee joint were decreased. In the histological analysis, the cartilage destruction, synovial cell proliferation and the collagen fiber destruction were decreased in the AR-P group. Conclusions: The results suggest that AR-P at right ST36 has a therapeutic effect on collagen-induced arthritis in mice.