The level of UV radiation emitted by the sun is increasing due to the destruction of the ozone layer. Our skin is more exposed to UV radiation and often suffers from various harmful effects of UV. Melanin production in human skin is an important defense mechanism against UV and a major determinant of skin color. Despite the protective role of melanins, abnormal hyperpigmentation such as freckles, chloasma, and other forms of melanin hyperpigmentation sometimes can be serious aesthetic problems. Because of this effect of melanin, people have concerned the effect of whitening in cosmetics. Taurine has been shown to be tissue-protective in many models of oxidant-induced injury, and it is a powerful regulator of the immune system, anti-oxidant effect. I investigated the whitening effect of Taurine. The Cytotoxicity was measured by MTT assay. I measured the level of tyrosinase activity and inhibition of the melanin synthesis in B16F10 murine melanoma cell. To evaluate effects of taurine on enzyme related tyrosinase I examined tyrosinase activity, TRP1, TRP2 by western blot and RT-PCR. Through such experiments, I gained the results that Taurine is able to be potential skin whitening agents in cosmetics.