The purpose of this study is to investigate the antioxidant activities of SanDalWood oil by experimental methods. For this purpose, first, we put an emphasis on the control of enzymes of the antioxidant system in various changes inside the cell; these changes caused by the reactive oxygen species (ROS) which were brought about by the handling of Lipopolysaccharide(LPS) into the RAW264.5 cell line of the body each other. After that, we caused the acute oxidant symptom by the injection of 2,2`-azobis(2-aminopropane) dihydrochloride(AAPH) into the mouse` abdominal cavity, and then applied the aroma SDWD oil orally administration, and finally, we measured the resistance against the activated oxygen of the red blood cell membrane, MDA, SOD, and catalase.