Sarcoidosis is a multisystem disorder that`s characterized by non-caseating granuloma that involves the lung, lymphatic system, skin, eye and other visceral organs. There are many treatment modalities such as corticosteroid, antimalarial agents and methotrexate, but only a few cases treated with isotretinoin have currently been reported. A 31-year-old male patient presented with a two month history of solitary erythematous plaque on the philtrum without other systemic symptoms. The histopathologic findings revealed several naked noncaseating granulomas in the dermis. Special staining such as PAS and AFB showed negative findings. The patient was diagnosed with cutaneous sarcoidosis, and this showed complete remission after a 4-months of therapy with oral isotretinoin (20 mg/day). (Korean J Dermatol 2009;47(5):629~631)