In order to investigate the anti-stress effect of Hyangbujapalmultnag in immobilization stress rats, the change of body weight, and, the humoral and cellular immune response were measured. The following results were obtained. 1. The decrease of the body weight was significantly inhibited in test group, comparing with the control group. 2 In the plaque fomation test, the number of the plaque in the control group was decreased but, the decreased in test group was significantly inhibited, comparing with the control group. 3. In the hemagglutination titer, the control group was decreased on the serum antibody titer, but, the decreased in test group was significantly inhibited, comparing with the control group. 4. In the footpad swelling response, the differences between the control and test group were not shown.