The objective of this paper is to verify clinical effects of Lyu`s Soyosan(柳氏逍遙散) and Lyu`s Kwipithang(柳氏歸脾湯). They were prescribed to the enperimental student group suffering from mental stress and annoyed by psychological instability. From the biochemical examination before and after medication, we measure the amount of hormonal variation in thyroid hormone(TSH, T_4) and adrenocortical hormone(ACTH, cortisol) The results are as follows. 1. The average of self-rating anxiety scale(SAS) in test group is 41.00 ± 7.84. This value is statistical significant and higher than one of normal person(age 20-39). The average of a global assesment of recent stress(GARS) scale is 28.62 ±9.00. There is statistical correlation coefficient between SAS and GARS (p < 0.001). 2. Both Lyu`s Soyosan(柳氏逍遙散) and Lyu.s Kwipithang (柳氏歸脾湯) groups show statistically significant reduction of total cholesterol and triglyceride level in serum lipid after ten day medication. 3. It is observed that Lyu`s Soyisan(柳氏逍遙散) and Luy`s Kwipithang (柳氏歸脾湯) groups have increasing tendency of TSH. The statistically significant reduction of T_4 was found in two groups after ten day medicaton. 4. It is observed that Lyu`s Soyosan(柳氏逍遙散) and Lyu`s kwipithang (柳氏歸脾湯) group have statistically significant reduction of serum cortisol level after ten day medication, Both groups have statistically significant reduction of plasma ACTH level after twenty day medication. From these results, it is verified that both Lyu`s Soyosan(柳氏逍遙散) and Lyu`s Kwipithang (柳氏歸脾湯) have anti-stress effects against psychological instability and mental stress. The Lyu`s Soyosn(柳氏逍遙散) shows special effectiveness in depression of liver-energy(肝氣鬱結) and the Lyu`s Kwipitang (柳氏歸脾湯) is also effective in deficiency heart-blood(心血不足).