This study was conducted in order to study the anti-stress effect of Kyogamdan and Sohaphyangwon, and the changes of serum catecholamine, aldosterone and cortisol levels were measured. In this study author gave immobilization stress to rats and got the following results. 1. The contents of norepinephrine in control group were 4.26 ± 0.50, 3.72 ± 0.31ng/㎖ 3hr, 6hr after an oral administration of Nacl, but in sample A the contents were 3.12 ± 0.33, 3.20 ± 0.41ng/ ㎖ and in sample B were 3.50 ± 0.625, 2.49 ± 0.55ng/ ㎖. The difference was obvious. 2. The contents of epinephrine in control group were 7.01 ± 0.85, 6.50 ± 0.68ng/ ㎖ after 3hr, 6hr since Nacl was taken, but in sample A the contents were 4.95 ± 0.67, 4.45 ± 0.58ng/ ㎖ and in sample B were 5.87 ± 0.87, 4.33 ± 0.59ng/ ㎖. The real significance lies in 6hr after administration of Sample A and B. 3. The contents of cortisol in control group were 3.39 ± 0.04, 3.73 ± 0.04ng / ㎖, but in sample A were 2.99 ± 0.02, 4.74 ± 0.04, and in sample B were 2.69 ± 0.03, 3.79 ± 0.03ng / ㎖. The real significance lies in 3hr since sample A and B were taken. 4. The aldosterone contents in control group were 1121.90 ± 71.90, 1454.30 ± 168.50 pg / ㎖, but in sample A were 1198.20 ± 69.10, 1257.50 ± 180.70 and in sample B were 776.30 ± 79.10, 1367.00 ± 170.10 pg / ㎖. The real significance lies in 3hr Sample B was taken. Base on the results above, it may be concluded that Kyogamdan and Sohaphyagwon are effective to prevent the changes by stress and Sohaphyangwon is better effective than Kyogamdan to prevent stress.