최근 저자들은 매우 드문 종양인 췌장 선방세포암으로 근치적 원위부 췌장절제술과 비장절제술 시행 후 위의 단독 재발로 위전절제술과 다발성 간전이로 좌간절제술 후 보존적 capecitabine 항암화학요법을 실시하여 장기간 종양의 진행이 없는 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Acinar cell carcinoma of the pancreas is a rare tumor that constitutes 1~2% of all pancreatic cancers. The clinical and radiologic findings are inconclusive when diagnosing this disease. Acinar cell carcinoma progresses rapidly and metastasizes early, resulting in a poor prognosis. A 41-year-old man was admitted for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography (PET)-CT showed a splenic mass involving the pancreatic tail with increased 18F-fluorodeoxyglucose (18F-FDG) uptake. A primary radical distal pancreatectomy and splenectomy were carried out. The pathology revealed acinar cell carcinoma of the pancreas. Three months later, a gastric recurrence was detected and a total gastrectomy was performed. Four months later, multiple hepatic metastases were found and a left hepatectomy was carried out. During treatment with capecitabine, no evidence of tumor progression was observed for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma that did not progress for 14 months with capecitabine treatment. (Korean J Med 76:506-509, 2009)