Whether inflammatory markers are associated with cardiorespiratory fitness, body composition, and blood lipids across gender and ethnic groups remains less clear. We investigated the relations of white blood cell(WBC) count with cardiorespiratory fitness, body composition(percent body fat), and blood lipids, i,e, total cholesterol(TC), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), and triglycerides(TG), in 145 Korean female college students. We measured WBC count and blood lipids, and cardiorespiratory fitness levels were indirectly assessed by Harvard 5-minute step test. Pearson product-moment correlation was used to investigate the partial associations of WBC count with cardiorespiratory fitness, percent body fat, and blood lipids(TC, HDL-C, LDL-C, TG) after adjustment for age, cigarette smoking, alcohol intake, physical activity, and dietary habits. WBC count was inversely associated with cardiorespiratory fitness(r=-0.27) and positively associated with percent body fat(r=0.31) after adjust- ment for multiple risk factors. However, there was a weak and non-significant association between WBC count with TC(r=0.04), HDL-C(r=0.07), LDL-C(r=-0.13), and TG(r=0.02) respectively. We conclude that improvements in cardiorespiratory fitness may reduce white blood cell count, while being obese may increase white blood cell count in Korean female college students.