The purpose of this study is to investigate the physiolosical responses and subjective wear sensation to the clothes with different cellulose composition. The experimental garments were four types of cellulosic fabrics, respectively composed of 100%-cotton, 100%-Rayon, cotton/Flax 85/15, and rayon/Flax 85/15 (weft blended), were sewn in blouses with half-length sleeves. Four healthy women were chosen for this experiment. The condition of the experimental room were in two environments: Temp., 25±1℃, R.H. 60±3% and Temp., 30±1℃, R.H. 70±3%, and air velocity was maintained at 0.25m/sec, The results are as follows. 1) At 25℃, rayon blouse showed the pleasantest feeling because of its excellent humidity sensation and tactile sensation. At 30℃, rayon and flax blended blouse showed most comportable sensation. In both environments, blouse of 100% cotton showed the least pleasant because of high vapor pressure inside the blouse and bad tactile sensation. 2) Vapor pressure inside the blouse and tactile sensation play the most impotant role in comfort. Consequantly, the blouse made of 100%-cotton which bring low air permeability, moisture regain and water vapor permearbility showed more unpleastness than rayon blouse because it raises temperature, relative humidity and vapor pressure inside the blouse under the hot circumstances. In the conditions with much sweat, rayon and flax blended blouse with high stiffness increases comfort better than 100% rayon because the former prevents sticking to the skin.