This paper focused on an overview of the Transtheoretical Model (TTM) of Change, which has been the basis for developing effective interventions to promote health behavior change and demonstrated applications of the TTM. The TTM which describes how people modify a problem behavior or acquire a positive behavior and an integrative model of behavior change, developed by Drs. Prochaska and DiClemente in 1983. Key constructs from other theories are integrated: the central organizing construct of the model is the stages of change and the model also includes the processes of change, the decisional balance and the self-efficacy/temptation. Based on the review of Korean literatures and interventions using the TTM in this paper, future studies in nursing practice are suggested: 1) a study including a larger sample size; 2) a study testing the key constructs of the TTM and/or a concept analysis in Korean population including the consideration of a cultural context and measurement`s issues; 3) a factor analysis and/or discrimination analysis for the most influential mechanisms/strategies which can discriminate each changing stages; and 4) an intervention study examining its effectiveness in a variety setting including an appropriate measurement of the key constructs of the TTM.