In this study, a simulation model for the adsorption of bacteriophage T4 lysozyme onto hydrophilic silica surfaces has been investigated. The concentration-dependent adsorption mechanism has been analyzed with respect to an adsorption model that allows two different adsorbed states. By utilizing a pair of stability mutants of T4 lysozyme, the adsorption behavior was characterized in terms of two adsorption parameters, α and β. The adsorption parameters in the model were represented as a function of the adsorption time. The simulation results demonstrate that the estimated model parameters predict the adsorption kinetic data appropriately at all of the concentrations used.