6가크롬의 일정량(1, 5, 10㎍)을 부란 직전, 부란 3일째, 6일째에 난황내에 투여하여 부화 14일째에 계배를 적출하여 6가크롬이 계배의 생존과 간세포의 DNA, RNA및 protein 함량에 미치는 영향을 조사하고, 발생후기 즉 부란 13일째의 계배에 6가크롬을 투여하여 시간 경과에 따른 간세포의 DNA, RNA 및 protein함량에 미치는 영향을 조사하였다. 부란직전에 6가크롬을 10㎍ 투여했을때 사망율이 55%로 50%이상의 치사율을 나타내었다. 6가크롬의 치사작용과 간세포의 DNA, RNA및 protein 함량에 미치는 영향은 처리시가 빠를수록 컸으며 처리양에도 비례하였다. DNA와 protein 보다도 RNA 감소량이 더 컸는데 이는 6가크롬의 독성영항이 일차적으로 전사과정에 나타남을 암시한다. 부란 13일째 계배에 6가크롬을 투여한 1일후보다 3일후에 간세포에서의 DNA, RNA 및 protein 함량이 더욱 감소되었고 5일, 7일 시간이 경과함에 따라 회복되는 경향을 보였다.

Cr^(6+)(1, 5 and 10㎍) was injected into the yolk sac of the fertilized eggs at certain time(0, 3 and 6 days) after incubation. At 14 days after incubation, the effects of Cr^(6+) on the mortality and the contents of the DNA, RNA and protein in surviving chick embryo liver were inverstigated. The other group injected Cr^(6+) at 13 days after incubation, the effects of Cr^(6+) on the contents of the macromolecules in chick embryo liver with the passing of time were investigated. When Cr^(6+) was injected just before incubation, the LD_50 was 10㎍. The longer and more expose to Cr^(6+), the more increeasingly the mortality and the decrease in the contents of the macromolecules. Decrease in the content of RNA was the most remarkable as compare to that of DNA or protein. It is suggest that the toxicity of Cr^(6+) firstly effect the transcriptional process. In the condition Cr^(6+) was injected into eggs which were incubated for 13 days. The contents of the macromolecules of liver after 3 days from injection decreased much more that of 1 day from injection. While, as time passed(after 5 and 7 days from injection) and contents of the macromolecules of liver recovered.