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SCIE SCOPUS
Purification and Characterization of Aspartase from Hafnia alvei
Moon Young Yoon, Jae Ho Park, Kyong Jae Choi, Joung Mok Kim, Yeon Ok Kim, Jun Bum Park, Jin Burm Kyung
BMB Reports 31권 4호 345-349(5pages)
UCI I410-ECN-0102-2008-470-001579351

Aspartase (EC 4.3.1.1) from Hafnia alvei was purified to homogeneity by a combination of DEAE-cellulose, Red A-agarose, and Sepharose 6B chromatography. The purified enzyme appeared homogeneous on denatured SDS-polyacrylamide gel electrophoresis. The purified enzyme was a tetrameric protein composed of identical subunits with a molecular weight of 55,000 daltons. The optimum pH for the enzymatic reaction was 8.5 and the optimum temperature for maximum activity was 45℃. The enzyme has an absolute requirement of divalent metal ions (Mg^(2+), Mn^(2+)) at the alkaline pH. The enzyme, however, was inactivated in the presence of other divalent cations such as Zn^(2+), Ca^(2+). The helical content of the purified enzyme was estimated by CD spectropolarimetry to be 61 %.

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