Explosive cladding is best known for its capability to join a wide variety of both similar and dissimilar combinations of metals that cannot be joined by other conventional metal joining techniques. An attempt has been made to optimize the tensile and shear strengths of an explosive clad interface using fuzzy logic and genetic algorithm. The parameters considered for this study include flyer plate thickness, loading ratio, angle of inclination, and stand off distance. The experimental data was trained and simulated using fuzzy logic and the optimization of process parameters was performed using genetic algorithm. The optimized process parameters were validated using experimental results.