The present study examined functional effects of a new selective phosphodiesterase type 5inhibitor,1-[4-ethoxy-3-(6,7-diydro-l-methyl-7-thioxo-3-propyl-1H-pyrazolo[4,3]pyrimidin-5-yl)phenylsulphonyl]-4-methyl piperazine(KJH-1002), in the isolated rabbit corpus cavernosum(RCC). Relaxing effects of KJH-1002 were also compared with those of sildenafil, which is currently used as an oral therapy for penile erectile dysfunction. In the isolated RCC precontracted with phenylephrine, both KJH-1002 and sildenafil in the concentration range of 1 to 100nM, produced a comparable potentiation of the electrical field stimulation-induced relaxation in a concentration-dependent manner. In the sodium nitroprusside(SNP)-induced relaxation, the C_(50) values, concentrations of SNP required to produce a 50％ relaxation of the phenylephrine-induced contraction, were significantly decreased to the similar extent by treatments with KJH-1002 and sildenafil. The results suggest that a new selective phosphodiesterase type 5 inhibitor, KJH-1002, has an augmentative effect on penile erection comparable to that of sildenafil and can be useful for the treatment of erectile dysfunction.