여러종류의 리파제를 이용하여 (±)-2-(4-chlorophenyl)-2-cyano-2-phenyl-1-hexanol(2)와 이의 acetate ester(3)을 광학분할하고 분할된 화합물들을 이용하여 (R) 및 (S)-systhane의 항균활성을 조사하여 2 ppm의 농도에서 모든 systhane이 밀붉은녹병과 보리흰가루병에 대하여 92%의 항균활성을 보여주었으나 (R) 및 (S)-systhane이 (±)systhane보다 더 좋은 항균활성을 보여주지는 않았다.

(±)-2-(4-Chlorophenyl)-2-cyano-2-phenyl-1-hexanol (2) and acetate ester (3) were resolved by various lipases. (R) and (S)-systhane were synthesized by the resolved compound 2. The antifungal screening of (R), (S)-systhane and (±)-systhane against wheat leaf rust and barley powdery mildew gave activity over 92% in concentration of 2 ppm, but (R)-and (S)-systhane were not more active than (±)-systhane.