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SCOPUS
3×2 교차설계법에서 생물학적 동등성 시험의 통계분석
Statistical Analysis of Bioequivalence Study in 3X2 Crossover Design
박상규(Sang Gue Park), 김정일(Jeong Il Kim), 채성산(Sung San Chae), 고승곤(Seoung Gon Ko), 오현숙(Hyun Sook Oh), 양완연(Wan Youn Yang), 김동섭(Dong Sup Kim), 최영욱(Young Wook Choi)
약제학회지 28권 4호 231-239(9pages)
UCI I410-ECN-0102-2008-510-001525276

A 3×2 crossover design is considered for the bioequivalence of two test formulations with a control. It could be considered as a better choice over 3×3 crossover design because of the cost and experimental duration. Oh et al.(1998) derived 3×2 crossover design and discussed its benefits over the typical crossover designs. We consider here the statistical models for 3×2 crossover design and show its statistical properties. The statistical procedures for the bioequivalence in 3×2 crossover design are shown through an example and the results are summarized by satisfying the 3 standards that proposed by the Korea Food and Drug Administration Guidelines for Bioequivalence.

[자료제공 : 네이버학술정보]
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