In this study, we investgated the effect of Red Ginseng (KRG) on liver damage induced by carbon tetrachloride (CTC) and galactosamine (GalN) in rats using indicator enzymes such as serum alanine/aspartate aminotransferases, sorbital dehydrogenase, lactate dehydrogenase, and γ-glutamyltransferase. Tretment of KRG restored these enzyme activities to near normal level compared to CTC or GalN treatment alone, Treatment of KRG enhanced hepatic microsomal enzyme system, malondialdehyde formation, and depletion of reduced glutathione content, which were reduced by CTC or GalN. We also found that the decreased activities of glutathione S-transferase and glutathine reductase but not γ-glutamycysteine synthetase after KRG treatment restored to normal level. These results indicate that KRG has potnet therapeutic activity against CTC- and GalN-induced hepatotoxicity in rat.