This study was conducted to investigate the changes in contents of dermal proteoglycans(PGs) on enrymolytic measurement during the hair growth cycle in mink. The results obtained from this research are as follows The total PG contents of mink dermis were high in infants(5 weeks old) and winter anagen(22 weeks old), while the contents were low in summer and winter telogens(15 weeks and 30 weeks). The ratios of PG to collagen content in infants and winter anagen were higher(30 and 25%) than those in summer and winter telogens(16 and 17%). Hyaluronic acid contents of mink dermis were low in infants and anagen, while high in summer and winter telogens. The contents of condroitin sulfate, dermatan sulfate and heparan sulfate of mink dennis were high in infants and anagen, while low in the both telogens. Comparing the PG digestibility by protein resolving enzyme such as pepsin, the PG in the anagen was more hardly dissoved than that in the telogen. The tolerance of PG to protein-denaturant such as guanidine-HCl was higher in the anagen than in the telogen.