We present two cases of plexiform schwannoma, a benign peripheral nerve sheath tumor, characterized by a plexiform growth pattern. Plexiform schwannoma must be distinguished from plexiform neurofibroma because of the propensity of the latter for malignant degeneration. Although plexiform schwannoma usually arises sporadically, it can be rarely associated with neurofibromatosis type 2. We report two cases of plexiform schwannoma. One was single sporadic lesion on the abdomen of a 28-year-old woman. The other showed multiple plexiform schwannomas associated with bilateral acoustic neuromas.