The purpose of this study to examine lipid profiles and lipoprotein (a) concentrations and identify the risk factors of type 2 diabetes mellitus patients with macrovascular complications. The subjects were consisted of 618 out patients with type 2 diabetes mellitus from beginning of March through the end of April in 2001, who visited at the endocrinology department at Kangnam St. Mary`s Hospital of Catholic University in Seoul. The patient`s clinical laboratory data and the occurrence of chronic complications of diabetes were assessed at medical record review. The data were analyzed using for t-test, chi-square test and logistic regression. The results were as follows : 1. There were no significant differences in age, duration of diabetes, body mass index, sex, fasting blood glucose, 2-hour postprandial blood glucose and HbA_1c level between macrovascular complication group and non macrovascular complication group. 2. There were significant differences in the level of total cholesterol, triglyceride, HDL(High density lipoprotein) cholesterol, LDL(Low density lipoprotein) cholesterol and lipoprotein(a) between macrovascular complication group and non macrovascular complication group. 3. Significant factor associated with macrovascular complication in the logistic regression best gut model was HDL cholesterol.