Hypoalbuminemia due to gastrointestinal loss of protein has been reported in association with many pathologic conditions of stomach and bowel. We have recently experienced a 63 year old man with stomach cancer presenting with generalized edema. The patient .had severe hypoalbuminemia and we confirmed protein loss through the gastric mucosa as its cause by 99mTc labled albumin scan and alpha 1 antitrypsin clearance test. The possiblility of other coincidental gastrointestinal lesion was excluded. After total gastrectomy, hypoalbuminemia was corrected to normal range without replacement of albumin and follow up albumin scan revealed no albumin loss. To our knowledge there have been a few case reports of protein losing gastroenteropathy due to stomach cancer. Therefore, it is recommended to exclude cancer at first, when an etiologic diagnosis is scheduled for the differentiation of protein losing enteropathy in this country