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고밀도 막내침착을 동반한 막증식성 사구체신염 1 예
Membranoprolirerative Glomerulonephritis with Dense Intramembranous Deposits고밀도 막내침착을 동반한 막증식성 사구체신염 1 예
손호선(Ho Sun Son),고동혁(Dong Hyuk Ko),김향(Hyang Kim),이만호(Man Ho Lee),정을순(Eul Soon Chung),이상종(Sang Jong Lee),원남희(Nam Hee Won)
UCI I410-ECN-0102-2009-510-004691284

Membranoproliferative glomerulonephritis (MPGN) with dense intramembranous deposits, so-called type II MPGN, is a subtype of idiopathic MPGN, and was described as a separate entity by Berger and Galle in 1963. It frequently occurs in older children and young adults and the clinical course is variable, but is generally progressive. The presenting feature is nephrotic syndrome in many patients, and proteinuria and hematuria are also seen frequently. Recently we experienced a case of type II MPGN which was proven by renal biopsy. A 14-year-old school boy was admitted to this hospital because of generatlized edema and hematuria which developed three weeks after an upper respiratory infection. The histopathologic findings showed a thickened capillary basement membrane with a tram-track appearance and epithelial crescent formation on light microscopy, and a characteristic rihbon-like appearance of the glomerular basement membrame with electron-dense deposits on electron microscopy. The patient received triple drug therapy including corticosteroid, dipyridamole and cyclophosphamide without improvement.

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