Two cases of protein-losing enteropathy are reported. Protein-losing enteropathy due to constrictive pericarditis was diagnosed in a 17-year-old boy with a 1 year history of intermittent generalized edema and pleural effusion. His symptoms completely disappeared after a pericardiectomy. Another case of protein-losing enteropathy was found in a 23-year-old woman with a 4 year hstory of intermittent generalized edema and ascites. After an explorative laparotomy, intestinal lymphangiectasia was diagnosed. A low fat diet and oral prednisolone were prescribed and the patient returned to relatively good health without edema for 15 months.