Hepatic solitary tuberculoma is an extremely uncommon condition. However it is found frequently with the use of liver biopsy. On the other hand, although miliary tuberculosis of the liver occurs more often than the localized form, the incidence has been decreasex with the introduction of modern treatment for tuberculosis. A 36-year-old man presented to us with a history of low grade fever, anorexia, and ascites. The chest X-ray showed plural effusion on the left side. A technetiumsulfur colloid liver scan demonstrated a well defined filling defect in the right lobe of the liver. The ultrasonogram and computed tomogram of the liver showed a well defined solid mass in the right lobe. Fine needle aspiration of the mass showed necrotic material and normal hepatocytes. The laparotomy revealed a solitary tuberculoma. The liver biopsy showed a large amount of caseation necrosis bordered by epithelioid cell granulomas characteristic of tuberculosis. Acid-fast bacilli were demonstrated in the biopsy material.