Hemorrhage from esophageal varices is a difficult problem for which there is no completely solution, Sixty-three patients (eight-five cases) have been treated with endoscopic injection sclerotherapy (EIS). All patients had documented variceal hemorrhage and underwent EIS while bleeding or shortly thereafter. The observed results are summarized as follows: 1) The duration of EIS from onset of hematmesis and/or melena was within 72 hours mostly, and the frequency of EIS was one to six times. 2) There were no noticable changes in Hemoglobin, SGOT, Serum bilirubin and serum albumin before and after EIS. 3) The amounts of blood transfusion was decreased significantly after EIS. 4) There were mild complications after EIS, but were serious complication or death relate to EIS. 5) The mortality rate was 13% in follow up period. Based on these results, we concluded that EIS is recommanded for managing variceal hemorrhage with- out serious complication.