This report is of 81 anesthetic experiences of renal homotransplantation performed under general anesthesia from December 1984 to April 1988 at Kosin Medical Center. Our anesthetic procedures in the recipients were as follows: 1) Preanesthetic preparation with dialysis. 2) Premedication with Robinul and Demerol. 3) Thiopental and succinylcholine for anesthetic induetion. 4) N2O-O2-relaxant (pancuronium and/or norcuron) with halothane or enflurane for maintenance. 5) Antagonism against the relaxant with neostigmine or pyridostigmine. 6) Transfusion and fluid infusion with which CVP was maintained around 10 cm H2O. These patients had several common problems of significance to anesthesiologists, including anemia, coagulopathies, electrolyte imblance, acidosis, hytertension with associated therapy, previous therapy with steroids and immunosuppressants, and dialysis etc. As well as the problems listed above, we experienced a case of protrusion of a grafted kidney due to inadequate relaxation, several cases of bradycardia which did not respond to intravenous atropine during anesthesia, and 5 cases of delayed recovery of respiration.