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18.97.14.82
18.97.14.82
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Candidate
위의 양성 및 전암성 병변에서 Telomerase 활성화와 Helicobacter pylori 감염의 연관성
Relationship between the Telomerase Activation and Helicobacter pylori Infection in Benign and Precancerous Lesion of the Stomach
장현주(Hyun Joo Jang),김정한(Jung Han Kim),홍수진(Su Jin Hong),강승식(Seung Sik Kang),계세협(Sea Hyub Kae),이 진(Jin Lee),주상언(Sang Aun Joo)
UCI I410-ECN-0102-2009-510-004919394

Background/Aims: It has been considered that motor abnormalities of the oropharynx might play a role in the pathogenesis of oropharyngeal dysphagia. This study aimed to evaluate the motility change in patients with oropharyngeal dysphagia using circumferential solid state manometry. Methods: Nineteen patients with oropharyngeal dysphagia and 12 healthy volunteers of similar age underwent circumferential solid state manometry and lateral videofluoroscopic studies to assess oropharyngeal motility. The patients were divided into 3 groups by videofluoroscopic findings: group 1, patients with delayed oral transit; group 2, patients with increased pharyngeal residue; group 3, patients with aspiration alone. Results: The group 2 showed less upper esophageal sphincter relaxation and lower amplitude of hypopharyngeal contractions. The time interval from the onset of hypopharyngeal contractions to the onset of complete upper esophageal sphincter relaxation was delayed in the group 3. Post-swallow aspiration was caused by high pharyngeal residue in patients with oropharyngeal dysphagia. Conclusions: These results suggest that a high pharyngeal residue is related to a weak contraction of the hypopharynx, and aspiration is related to a slowed swallow response, presumably with delayed laryngeal closure. (Korean J Gastroenterol 2001;38:9-14)

[자료제공 : 네이버학술정보]
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