Tuberculosis of the liver is uncommon. Subsequent development of jaundice during antituberculous chemotherapy is usually caused by the side effects of drugs. The case of obstruction of the extrahepatic biliary system by tuberculous lymphadenopathy causing obstructive jaundice is extremely rare. A 18- year-old man was admitted to the hospital due to jaundice. He had the medical history of tuberculous pleurisy treated by antituberculous chemotherapy for about 4 months. Abdominal ultrasonography and computed tomography revealed a 3.4 cm-sized soft tissue masses at periportal area. Endoscopic retrograde cholangiography showed nearly complete luminal obstruction of the distal common bile duct. Ultrasound-guided fine needle aspiration and biopsies showed epithelioid histiocytes and necrotic materials. Endoscopic nasobiliary drainage and successive antituberculous chemotherapy resolved obstructive jaundice and lymphadenopathy without surgical management. We report a case of obstructive jaundice due to tuberculous portal lymphadenitis. (Kor J Gastroenterol 2000;35:820 - 825)