We experienced a 29-year-old woman, who was negative for human immunodeficiency virus (HIV) antibodies and developed Kaposi's sarcoma. It infiltrated into generalized-skin, stomach, duodenum, lung and ureter. She had received kidney transplantation for lupus nephritis followed by the immunosuppression with cyclosporin and deflazacort. Reduction of the immunosuppressive therapy with chemotherapy led to a remission of Kaposi's sarcoma without development of tranplant rejection. (Kor J Gastroenterol 1999;34:537 - 541)