The gallbladder perforation was found in patients of cholecystitis with alarmingly high mortality rate. These high morbidity and mortality rates were caused by the delay in diagnosis. Therefore early dianosis and early operative intervention can decrease the confirmatively by demonstration of extravasated contrast media from the lumen of the gallbladder into loculated spaces around it. The purposes of our study are to review the clinical manifestations and values of endoscopic retrograde cholangiography in diagnosis of perforation of the gallbladder.