To evaluate the effect of 400 mg of cetraxate twice daily on healing of benign gastric ulcer in comparison with that of 200 mg of cetraxate three times daily, 55 patients with benign gastric ulcer were randomly assigned to either group and given each medication for 8 weeka After 8 weeks of medication the effect of each medication was compared between the two groups with respect to subjective symptoms, degree of ulcer healing by endoscopy, general improvement, adverse reactions and overall effectiveness. In the group of patients given 400 mg of cetraxate twice daily (27 patients), general improvement rate above a moderate degree was 81% and no serious adverse drug reactions were observed. In the group of patients given 200 mg of cetraxate three times daily (28 patients), general improvement rate above a moderate degree was 75% and no adverse drug reactions were not observed either. Comparison of general improvement rate between the two groups showed no difference statistically. Patient compliance to medication did not differ between the two groups, so it seemed that the effects of each medication on ulcer healing were equally effective. Considering that the regimen of 400 mg of cetraxate twice daily is superior to that of 200 mg of cetraxate three times daily in terms of convenience, we conclude that the former. is superior to the latter.