Adenosquamous carcinoma of the pancreas has a mixture of adenocarcinoma and squamous cell carcinoma components and is uncommon. We presents one case of adenosquamous carci- noma of the pancreas in old man aged 76. His chief cornplains were intermittent abdorninal discomfort and pain. Physical examination revealed huge abdominal mass in left upper quad- rant abdomen. All laboratory data were not significant. Abdominal ultrasonography and CT scan revealed a well demarcated cystic and solid mass which was located at the tail of the pancreas. Successful resection of the tumor by splenectomy, total gastrectomy and segmental resection of transverse colon were carried out. Cut section of the resected specimen reveals a huge cyst locating between the serosal surface of the stomach and pancreas and an oval round solid mass with infiltrating margin of the distal pancreas. Histopathologically, the tumor was composed of adenocarcinorna, well differentiated squamous cell carcinoma and anaplastic car- cinoma with transition areas. The cyst was partly lined by mesothelial cells and poorly differentiated squamous cell carcinoma. The patient was discharged without specific prob- lem. But he died 6 months after operation.(Korean J Gastroenterol 1994; 26: 885 891)