It has been well known that pancreatic tumors occasionally show incidious symptoms resembling chronic pancreatitis as the first manifestation. However, only a few cases were reported about manifestation like acute pancreatitis, confined to pancreatic adenocarcinoma or metastatic carcinomas and there is no clear descriptive report about pancreatic lymphoma associated with acute pancreatitis. Lymphoma of the pancreas itself is a rare neoplasm compris- ing less than 0.16% of all pancreatic malignancies. It is important to exclude other diseases in early clinical course in spite of its difficulty in differential diagnosis because lymphoma is po- tentially curable with chemotherapy or radiation therapy. We report a case of pancreatic non Hodgkins lymphoma presenting with acute pancreatitis as the first manifestation in 34 year old women. In the case, lymphoma was suspected on the basis of clinical and radiological findings and, after histopat,hologic diagnosis obtained from the specimens of metastatic sites, we stanted chemotherapy(COPBLAM) as anecpirical trial. The response was as good as we expected.(Korean J Gastroenterol 1994; 26: 758 763)