The association of acute pancreatitis with hyperlipidemia has been well known for many years. Acute pancreatitis may be associated with both primary and secondary hyperlipemia. Acute pancreatitis usually occurred when serum triglyceride levels were above 1,000 mg/dl. Most of the investigative works has been carried out on patients who have alcohol-induced hyperlipemia and pancreatitis. The excessive alcohol consumption can initiate an episode of acute pancreatitis. However, the pathogenetic pathway by which alcohol ingestion induces pancreatitis is unknown. Alcohol ingestion is known to increase serum triglyceride level due to an elevation of VLDL in many individuals. The increased serum triglycerides act as an important intermediary in the pathogenesis of acute pancreatitis in some alcholic patients. We experienced a case of acute pancreatitis with increased serum triglyceride levels (3,058 mg/dl) secondary to alcohol ingestion and uncontrolled diabetes mellitus. We report this case with the review of the literature.