The hepatocelluar carcinama is the most common cancer in the liver with various paraneoplastic syndromes. The hypoglycemia or hypercgolesterolemia are found in a third of hepatocellular car-choose patients independently. The combined cases of the hypoglycemis, and hypercholesterolemia were rare in the hepatocellular carcinama. So we report one cases of 66 years old male of hepatocellular carcinoma. with hypoglycemis and hypercholesterolemia presenting unconciousness initialy.