Several drugs known to be vasodilators and/or membrane stabilizers were studied to evaluate whether these would have protective effects against experimental eschemia-reperfusion induced liver injury in rats. The aninmals were divided into six groups-control, treatment with pentoxifylline, aprotinin, FDP, verapamil, and sham operation. Drugs were administered systemically through IVC 5 minutes before induction of ischemia. The hepatic arterial and portal venous blood supply to the left lateral and median lobes of the liver was interrupted with an surgical clip for 90 minutes to induce hepatic ischemia, and after then the clip was removed for reperfusion. The arterial blood SGOT, SGPT, ALP, LDH, and hepatic MDA were measured before and 90 minutes after ischemia, and at the end of 60 minutes reperfusion. The control group showed sharp elevation of the all liver enzymes following both hepatic ischemia and reperfusion. However the treated groups with pentoxifylline, aprotinin, FDP, and verapamil demonstrated significantly lower level of liver enzymes compare with the values of the control group. Verapamil thought to be most effective in protection of liver from ischemia- reperfusion injury. The hepatic MDA l evel decreased during ischemia-reperfusion procedures, and showed no significant difference between control and treatment groups.