Peptic ulcer disease in early childhood is a relatively rare condition. Secondary ulcers, stress ulcer or drug-induced ulcer are more common in younger children. We experienced thirteen children less than 10-year old complicated drug-induced ulcers for last seven years. Ulcer perforations occurred in 8children who had steroid therapy and 5 children took aspirin had acute gastric ulcers with bleeding. In all cases with steroid-induced ulcer, generalized urticaria was the primary insult. The duration of steroid or aspirin therapy was only 3 to 5 days and daily dose did not exceed the mormal usual dosage. The ocurrence of drug-induced ulcers did not seem to be dose-dependent in this series.The diagnosis of the ulcer periorations was made by plain abdomial roentgenogram and in 5 patients with ulcer bleeding, the diagnosis was made by either endoscopy or barium meal. Morphologically, steroid-induced ulcers resimbled chronic peptic ulcers in adult, being duodenal, single and deeply penetrating prone to perforate compared with asprin-induced ulcers being gastrin, multiple and shallow prone to bleeding. Microscopic findings were also different. Mucosal destruction and the inliltration of infalmmatory cells,mainly eosinopgils, to the granulation tissue of the serosa were siin in the steroid-induced ulcers. In cases with asprin-induced ulcers, the mucasal layer was abruptly desquamated wuthout granulation tissus formation.Surgery was necessary for all patients with perforted ulcers and all bleeding ulcers recovered with conservative management.