Medical therapy is standard for intrahepatic abscess and generally effective, but frequently radiologically abnormal lesion persist for long time followed by ultrasonography(US) or abnormal C-T, even after successful medical treatment including aspiration and complete clinical recovery. To access the histologic features of medically healed abscess but not disappeared completely in follow-up US or ahdominal C-T we performed liver biopsies in 5 cases of healed liver abscesses. The biopsy specimens were obtained at the margin of the lesions by cutting needle with ultrasono- graphic guiding. The biopsies were performed one time in one patient at variable period after treatment, 4 weeks in 2 cases, 6, 12 weeks & 17 months in each one case. The lobular architecture of the liver was relatively well preserved except the 2 specimens obtained at 4 weeks after treatment. And the specimens within 2 months showed hemorrhagic features rather than inflammatory, such as central hemorrhagic necrosis with extravasation of RBC. The sinusaidal system was dilated slightly. Some fibrosis involving portal tract and parenchyme of the liver was noted in the specimen of 6 weeks and 12 weeks. The specimen obtained at 17 months after treatment showed nearly normal liver architecture except minimal infiltration of lymphocyte in portal tract and parenchyme. Therefore, we concluded that in completely healed liver abscess, enen if abnormal reaiologic lesion persist for long time, the histologic feature of the lesion showed some hemorrhagic necrosis and infiltration of chronic inflammatory cells.