To evaluate of the possibility of diabetes mellitus in the precipitating factor of liver cirrhosis, the authors have made a clinical analysis on 56 patients of diabetes mellitus with chronic hepatopathy (Cirrhotic Liver Group (29 cases): Noncirrhotic Liver Group (27 cases)} who were admitted at Pusan National University Hospital from Feb. 1987 to Jun. 1989. The results were as follows; 1) The mean age of DM group with cirrhosis was significantly older than that of DM group without cirrhosis (p<0.01). 2) On duration of DM, especially more than 6 years, DM group with cirrhosis was longer than that of DM group without cirrhosis (62% : 32%). 3) On fasting blood sugar level, especially more than 201 mg%, DM group with cirrhosis was higher than that of DM group without cirrhosis, and in cirrhotic group complications of portal hypertension were higher in high FBS level cases. 4) On body weight, especially range of IBW +- 10%, DM group with girrhosis was less controlled than DM group without cirrhosis (41% : 59%). 5) On complications of DM, both group are 76% and 71%, respectively, and the high incidence of complication suggest that duration of DM was long. 6) The positive rate of HBs Ag in DM group with cirrhosis was significantly higher than that of DM group without cirrhosis (28% : 4%, p<0.05). 7) On chemical liver function studies, DM group with cirrhosis showed more increased abnormal value except SGPT, total protein than that of DM group without cirrhosis. 8) On comparison of liver size by radiosotope liver scan, DM group with cirrhosis was smaller than that of DM group without cirrhosis (9.70 +- 1.59:12.68 +- 1.16, p<0.001). 9) On radiosotope liver scan, mottling of DM group with cirrhosis was coarse, but DM group without cirrhosis was fine (p<0.005), and spleen visualization in DM group with cirrhosis was more significant than that of DM group without cirrhosis (92% : 40%, p<0.001).