Percutaneous liver biopsies were performed in 146 patients with acute and chronic liver diseases, including neoplastic diseases. Among 146 patients, 28 patients had undergone liver biopsy under laparoscopic examination and 118 patients by blind intercostal biopsies. Ultrasonographic examination was performed before biopsy and 24 hours after biopsy. Blood pressure and pulse rate were also examined in all 146 hospitalized patients. The following results were obtained. 1) Development of intrahepatic hematoma was found by ultrasound in one case (0.6%) which the biopsy had been done under laparoscopic examination, however there were no significnt hemodynamic changes in blood pressure, hemoglobin level and pulse rate. 2) No significant hemodynamic changes noted between the prebiopsy and six hours after biopsy. 3) No other serious complications encountered in all 146 cases of liver biopsy. It is concluded that routine post-biopsy ultrasonographic examination may be unnecessary in patients undergone percutaneous liver needle biopsy if a skillful personnel and good indications were applied.