Hepatofugal flow (reversed flow) of portal vein is very rare, and its diagnosis is not so easy. Variable invasive procedures had been tried to demonstrate this rare hemodynamic change of portal vein, however there was many probrems in the routine clinical use of those procedures. Since clinical application of Doppler flowmetry system, repetitive observation of portal hemodynamics in physiologic condition has become easy. We observed 1 case of liver cirrhosis and 3 cases of bepatcellular carcinoma combined with liver cirrhosis who showed reversed flow of portal vein among 72 cases and 42 cases each other. All patients with hepatocellular carcinoma had thrombosis in main portal vein, and one of them showed hepatofugal flow of splenic vein. One patient with liver cirrhosis who had suffered spontaneous hepatic encephalopathy, had large splenorenal shunt and reversed flow of splenic vein.